Drawbacks ========= If you intensively check sequence names exists in FASTA file using ``in`` operator on FASTA object like: .. code:: python >>> fa = pyfastx.Fasta('tests/data/test.fa.gz') >>> # Suppose seqnames has 100000 names >>> for seqname in seqnames: >>> if seqname in fa: >>> do something This will take a long time to finish. Because, pyfastx does not load the index into memory, the ``in`` operating is corresponding to sql query existence from index database. The faster alternative way to do this is: .. code:: python >>> fa = pyfastx.Fasta('tests/data/test.fa.gz') >>> # load all sequence names into a set object >>> all_names = set(fa.keys()) >>> for seqname in seqnames: >>> if seqname in all_names: >>> do something